To minimize the risk of drug interaction, refrain from eating grapefruits or drinking grapefruit juice if you are taking one of the following drugs. Not everyone will react the same way it depends on which drug is involved, the grapefruit itself, and how sensitive you are to these effects. Grapefruit interactions are highly unpredictable. Drinking grapefruit juice in the morning, for example, and then taking your medication at night will not eliminate the risk of interaction. Because the effects of grapefruit last a long time, they cannot be avoided by spacing medication and grapefruit apart. The effects of grapefruit can last up to 3 days, sometimes even longer. Grapefruit contains substances that can interfere with the transformation and elimination mechanisms of certain drugs when they are administered orally, resulting in serious adverse reactions.Īs little as 200 mL of juice or a whole grapefruit can cause a significant increase of blood levels of certain drugs. Grapefruit and its juice (fresh or frozen) can either increase or, less frequently, decrease the effects of some drugs.
